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AllerMAbs.jpg

艾乐美生物科技有限公司(AllerMAbs Co., Ltd.)成立于2015年,是台湾一家专注于生产高亲和力、高纯度并具有过敏原特异性的嵌合人类IgE单克隆抗体的生物公司。公司创办人团队在科研过程中发现市面上缺乏多样的IgE单克隆抗体,特別是具有过敏原特异性的人IgE 单抗。如果能制备出这种抗体,将有助于IgE 相关领域的研究工作。因此,AllerMAbs公司团队开始思考与研究利用基因克隆动物来制造人类 IgE 抗体的可行性,经过数年的努力于 2014年开发出人类IgE 抗体基因嵌入小鼠,通过杂交瘤技术 (Hybridoma technology),成功地研制出分泌嵌合人类IgE 单抗的 IgE 杂交瘤与纯化 IgE 抗体。经测试,此种嵌合人类IgE 单抗的物化性质与对免疫细胞的活性,皆与人类IgE 抗体一致,研究成果于2015 年发表在国际学术期刊上。

 

AllerMAbs的产品解决了目前人类IgE抗体不易制备的问题,让嵌合人类IgE抗体可以成为人类IgE抗体的替代品,并提供一个更稳定、更符合血清IgE检测系统的校正品,让临床血清IgE的检测结果更加准确与可靠。

 

其利用动物基因转殖技术,将组成人类IgE抗体分子的ε重链(Heavy chain)和κ轻链(Light chain)的编码基因(Encoding genes),分別嵌入(Knock-in)小鼠胚胎干细胞(Embryonic stem cells, ES cells)的γ1重链和κ轻链基因的位置,接着把胚胎干细胞分別植入孕母鼠体内,并将其带有嵌入基因之成鼠交互配种,最后得到带有人类IgE抗体重链和轻链基因的基因嵌入小鼠(HεκKI mice),且体内能制造完整的嵌合人类IgE抗体分子。

 

技术优势

容易制备IgE杂交瘤与IgE单抗

过敏原特异性

良好的亲和力与专一性

高纯度与高稳定性

可结合至嗜碱性粒细胞上的IgE受体与刺激細胞

可大量生产与高浓度制备

非人类血液来源(相较于血清IgE抗体)

适合用作检测用的校正品

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Electron Microscopy Sciences.jpg

艾美捷科技特约代理Electron Microscopy Sciences公司产品。Electron Microscopy Sciences专注于制造、销售最高品质的实验室化学品、电子显微镜及其配件、光学显微镜及组织学相关产品。

 

Electron Microscopy Sciences specializes in the manufacturing, preparation and distribution of the highest quality laboratory chemicals and microscopy supplies and equipment for electron microscopy, light microscopy, and histology.

 

主要产品:

Chemicals for Electron Microscopy, Light Microscopy and Histology

ImmunoGold Reagents

Embedding Media Kits for the Biological & Materials Science

Graphene: Emerging Technology

Grids, TEM Support Films, Grid Staining & Storage

TEM Windows

Films for TEM

Silicone Nitride Mesh and Films

Calibration Standards, Specimens, and Aids

Microscope Accessories

Nanomanipulation and FIB Lift Outs

MAC Standards

AFM and STM Microscopy

Transmission Electron Microscopy

mPrep Specimen Preparation & Staining System

Specimen Preparation and Embedding Supplies

Material Sciences and Metrology

Silicon Wafer Cleaving System, Tools and General Accessories

Histology and Light Microscopy

Antigen Retriever

Scanning Electron Microscope Supplies

Cryo Supplies and Accessories

DiATOME Diamond Knives

Photography: Film and Supplies

Tweezers, Dissecting Tools, Instruments, and Gadgets

Illuminators, Magnifiers, Microscopes and Graticules

Air and Environmental

Cleaning Solutions and Accessories

Vacuum Pumps & Evaporation Supplies

Cell Stretcher

Vibration Isolation

Decontaminators and Cleaning Systems

Equipment and Accessories

Safety and Lab Organization

Labels, Tapes, Dispensers

Starter EM Kits

Technical Tips, Data Sheets, MSDS

Scientific Equipment Repair Center

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艾美捷科技有限公司

全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com

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